The research activites around the Interface Life Sciences / Physics are around three main axes : the radioisotopic and optical imaging for clinic and preclinic applications in cancerology and neutrobiology (nonlinear optical endomicroscopy, ambulatory gamma imaging for internal radiotheraphy and surgery, intracerebral probes), the new approaches in radiotherapy (spatial reduction of the dose in X-ray, protons and heavy ions and dosimetry in non-standard conditions) and the modelling of biological systems (growth of brain tumors, cell migration and prolferation, quantiative histology, intracell traffic).